Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Olig2  oligodendrocyte transcription factor 2   (Synonyms: Bhlhb1, bHLHe19, Olg-2, RK17)
Results	Reference
1	J:308693 Abbas E, Hassan MA, Sokpor G, Kiszka K, Pham L, Kerimoglu C, Fischer A, Nguyen HP, Staiger JF, Tuoc T, Conditional Loss of BAF (mSWI/SNF) Scaffolding Subunits Affects Specification and Proliferation of Oligodendrocyte Precursors in Developing Mouse Forebrain. Front Cell Dev Biol. 2021;9:619538
1*	J:130196 Alfonsi F, Filippi P, Salaun D, deLapeyriere O, Durbec P, LIFR beta plays a major role in neuronal identity determination and glial differentiation in the mouse facial nucleus. Dev Biol. 2008 Jan 1;313(1):267-78
1*	J:231103 Baroti T, Schillinger A, Wegner M, Stolt CC, Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes. J Neurochem. 2016 Jan;136(2):316-28
1	J:218900 Bischof M, Weider M, Kuspert M, Nave KA, Wegner M, Brg1-dependent chromatin remodelling is not essentially required during oligodendroglial differentiation. J Neurosci. 2015 Jan 7;35(1):21-35
1	J:297574 Bres EE, Safina D, Muller J, Bedner P, Yang H, Helluy X, Shchyglo O, Jansen S, Mark MD, Esser A, Steinhauser C, Herlitze S, Pietrzik CU, Sirko S, Manahan-Vaughan D, Faissner A, Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures. Glia. 2020 Dec;68(12):2517-2549
1	J:175804 Brzezinski JA 4th, Kim EJ, Johnson JE, Reh TA, Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina. Development. 2011 Aug;138(16):3519-31
1	J:95822 Cai J, Qi Y, Hu X, Tan M, Liu Z, Zhang J, Li Q, Sander M, Qiu M, Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling. Neuron. 2005 Jan 6;45(1):41-53
1	J:265822 Chapman H, Riesenberg A, Ehrman LA, Kohli V, Nardini D, Nakafuku M, Campbell K, Waclaw RR, Gsx transcription factors control neuronal versus glial specification in ventricular zone progenitors of the mouse lateral ganglionic eminence. Dev Biol. 2018 Oct 1;442(1):115-126
1	J:198563 Chapman H, Waclaw RR, Pei Z, Nakafuku M, Campbell K, The homeobox gene Gsx2 controls the timing of oligodendroglial fate specification in mouse lateral ganglionic eminence progenitors. Development. 2013 Jun;140(11):2289-98
1	J:160023 Cossais F, Sock E, Hornig J, Schreiner S, Kellerer S, Bosl MR, Russell S, Wegner M, Replacement of mouse Sox10 by the Drosophila ortholog Sox100B provides evidence for co-option of SoxE proteins into vertebrate-specific gene-regulatory networks through altered expression. Dev Biol. 2010 May 1;341(1):267-81
1	J:146618 Dasgupta B, Milbrandt J, AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development. Dev Cell. 2009 Feb;16(2):256-70
1	J:239292 Deneen B, Ho R, Lukaszewicz A, Hochstim CJ, Gronostajski RM, Anderson DJ, The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord. Neuron. 2006 Dec 21;52(6):953-68
1	J:291492 Dobrowolski M, Cave C, Levy-Myers R, Lee C, Park S, Choi BR, Xiao B, Yang W, Sockanathan S, GDE3 regulates oligodendrocyte precursor proliferation via release of soluble CNTFRalpha. Development. 2020 Jan 23;147(2):dev180695
1	J:209617 Ehrman LA, Nardini D, Ehrman S, Rizvi TA, Gulick J, Krenz M, Dasgupta B, Robbins J, Ratner N, Nakafuku M, Waclaw RR, The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon. J Neurosci. 2014 Mar 5;34(10):3767-78
1	J:289244 Elsesser O, Frob F, Kuspert M, Tamm ER, Fujii T, Fukunaga R, Wegner M, Chromatin remodeler Ep400 ensures oligodendrocyte survival and is required for myelination in the vertebrate central nervous system. Nucleic Acids Res. 2019 Jul 9;47(12):6208-6224
1	J:130977 Finzsch M, Stolt CC, Lommes P, Wegner M, Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor {alpha} expression. Development. 2008 Feb;135(4):637-46
1	J:157830 Flandin P, Kimura S, Rubenstein JL, The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons. J Neurosci. 2010 Feb 24;30(8):2812-23
1	J:181550 Frob F, Bremer M, Finzsch M, Kichko T, Reeh P, Tamm ER, Charnay P, Wegner M, Establishment of myelinating schwann cells and barrier integrity between central and peripheral nervous systems depend on Sox10. Glia. 2012 May;60(5):806-19
1*	J:152838 Fu H, Cai J, Clevers H, Fast E, Gray S, Greenberg R, Jain MK, Ma Q, Qiu M, Rowitch DH, Taylor CM, Stiles CD, A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci. 2009 Sep 9;29(36):11399-408
1	J:134976 Galichet C, Guillemot F, Parras CM, Neurogenin 2 has an essential role in development of the dentate gyrus. Development. 2008 Jun;135(11):2031-41
1	J:155627 Genethliou N, Panayiotou E, Panayi H, Orford M, Mean R, Lapathitis G, Gill H, Raoof S, De Gasperi R, Elder G, Kessaris N, Richardson WD, Malas S, SOX1 links the function of neural patterning and Notch signalling in the ventral spinal cord during the neuron-glial fate switch. Biochem Biophys Res Commun. 2009 Dec 25;390(4):1114-20
1	J:149261 Grimaldi P, Parras C, Guillemot F, Rossi F, Wassef M, Origins and control of the differentiation of inhibitory interneurons and glia in the cerebellum. Dev Biol. 2009 Apr 15;328(2):422-33
1*	J:231833 Hashimoto R, Hori K, Owa T, Miyashita S, Dewa K, Masuyama N, Sakai K, Hayase Y, Seto Y, Inoue YU, Inoue T, Ichinohe N, Kawaguchi Y, Akiyama H, Koizumi S, Hoshino M, Origins of oligodendrocytes in the cerebellum, whose development is controlled by the transcription factor, Sox9. Mech Dev. 2016 May;140:25-40
1	J:145299 Hochstim C, Deneen B, Lukaszewicz A, Zhou Q, Anderson DJ, Identification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain code. Cell. 2008 May 2;133(3):510-22
1	J:206315 Hoffmann SA, Hos D, Kuspert M, Lang RA, Lovell-Badge R, Wegner M, Reiprich S, Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes. Development. 2014 Jan;141(1):39-50
1	J:162581 Huillard E, Ziercher L, Blond O, Wong M, Deloulme JC, Souchelnytskyi S, Baudier J, Cochet C, Buchou T, Disruption of CK2beta in embryonic neural stem cells compromises proliferation and oligodendrogenesis in the mouse telencephalon. Mol Cell Biol. 2010 Jun;30(11):2737-49
1	J:259920 Ju J, Liu Q, Zhang Y, Liu Y, Jiang M, Zhang L, He X, Peng C, Zheng T, Lu QR, Li H, Olig2 regulates Purkinje cell generation in the early developing mouse cerebellum. Sci Rep. 2016 Jul 29;6:30711
1	J:119015 Kellerer S, Schreiner S, Stolt CC, Scholz S, Bosl MR, Wegner M, Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence. Development. 2006 Aug;133(15):2875-86
1	J:221657 Kong JH, Yang L, Dessaud E, Chuang K, Moore DM, Rohatgi R, Briscoe J, Novitch BG, Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling. Dev Cell. 2015 May 26;33(4):373-87
1	J:239986 Lahti L, Haugas M, Tikker L, Airavaara M, Voutilainen MH, Anttila J, Kumar S, Inkinen C, Salminen M, Partanen J, Differentiation and molecular heterogeneity of inhibitory and excitatory neurons associated with midbrain dopaminergic nuclei. Development. 2016 Feb 01;143(3):516-29
1	J:235955 Laitman BM, Asp L, Mariani JN, Zhang J, Liu J, Sawai S, Chapouly C, Horng S, Kramer EG, Mitiku N, Loo H, Burlant N, Pedre X, Hara Y, Nudelman G, Zaslavsky E, Lee YM, Braun DA, Lu QR, Narla G, Raine CS, Friedman SL, Casaccia P, John GR, The Transcriptional Activator Kruppel-like Factor-6 Is Required for CNS Myelination. PLoS Biol. 2016 May;14(5):e1002467
1	J:221126 Lee HK, Chaboub LS, Zhu W, Zollinger D, Rasband MN, Fancy SP, Deneen B, Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS. Neuron. 2015 Mar 18;85(6):1227-43
1	J:258230 Leferink PS, Breeuwsma N, Bugiani M, van der Knaap MS, Heine VM, Affected astrocytes in the spinal cord of the leukodystrophy vanishing white matter. Glia. 2018 Apr;66(4):862-873
1	J:206947 Li S, Mattar P, Dixit R, Lawn SO, Wilkinson G, Kinch C, Eisenstat D, Kurrasch DM, Chan JA, Schuurmans C, RAS/ERK signaling controls proneural genetic programs in cortical development and gliomagenesis. J Neurosci. 2014 Feb 5;34(6):2169-90
1*	J:110095 Ligon KL, Kesari S, Kitada M, Sun T, Arnett HA, Alberta JA, Anderson DJ, Stiles CD, Rowitch DH, Development of NG2 neural progenitor cells requires Olig gene function. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7853-8
1	J:242054 Lillien L, Rostral-caudal distribution of Emx1-lineage stem/transit amplifying cells and lineage progression in embryonic cortex depend on Hedgehog signaling. Dev Neurobiol. 2014 Nov;74(11):1096-109
1	J:87224 Liu R, Cai J, Hu X, Tan M, Qi Y, German M, Rubenstein J, Sander M, Qiu M, Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor. Development. 2003 Dec;130(25):6221-31
1	J:338173 Liu Z, Hu X, Cai J, Liu B, Peng X, Wegner M, Qiu M, Induction of oligodendrocyte differentiation by Olig2 and Sox10: evidence for reciprocal interactions and dosage-dependent mechanisms. Dev Biol. 2007 Feb 15;302(2):683-93
1	J:252094 Matuzelski E, Bunt J, Harkins D, Lim JWC, Gronostajski RM, Richards LJ, Harris L, Piper M, Transcriptional regulation of Nfix by NFIB drives astrocytic maturation within the developing spinal cord. Dev Biol. 2017 Dec 15;432(2):286-297
1	J:275078 Minocha S, Valloton D, Arsenijevic Y, Cardinaux JR, Guidi R, Hornung JP, Lebrand C, Nkx2.1 regulates the generation of telencephalic astrocytes during embryonic development. Sci Rep. 2017 Mar 7;7:43093
1	J:269506 Minocha S, Valloton D, Brunet I, Eichmann A, Hornung JP, Lebrand C, NG2 glia are required for vessel network formation during embryonic development. Elife. 2015 Dec 10;4:e09102
1*	J:171616 Moldrich RX, Mezzera C, Holmes WM, Goda S, Brookfield SJ, Rankin AJ, Barr E, Kurniawan N, Dewar D, Richards LJ, Lopez-Bendito G, Iwata T, Fgfr3 regulates development of the caudal telencephalon. Dev Dyn. 2011 Jun;240(6):1586-99
1	J:239534 Monaghan CE, Nechiporuk T, Jeng S, McWeeney SK, Wang J, Rosenfeld MG, Mandel G, REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E406-E415
1	J:267072 Newton K, Dugger DL, Sengupta-Ghosh A, Ferrando RE, Chu F, Tao J, Lam W, Haller S, Chan S, Sa S, Dunlap D, Eastham-Anderson J, Ngu H, Hung J, French DM, Webster JD, Bolon B, Liu J, Reja R, Kummerfeld S, Chen YJ, Modrusan Z, Lewcock JW, Dixit VM, Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain. Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):11244-11249
1	J:185426 Niola F, Zhao X, Singh D, Castano A, Sullivan R, Lauria M, Nam HS, Zhuang Y, Benezra R, Di Bernardo D, Iavarone A, Lasorella A, Id proteins synchronize stemness and anchorage to the niche of neural stem cells. Nat Cell Biol. 2012 May;14(5):477-87
1*	J:296266 Ogino H, Nakajima T, Hirota Y, Toriuchi K, Aoyama M, Nakajima K, Hattori M, The Secreted Glycoprotein Reelin Suppresses the Proliferation and Regulates the Distribution of Oligodendrocyte Progenitor Cells in the Embryonic Neocortex. J Neurosci. 2020 Sep 30;40(40):7625-7636
1	J:277848 Ohayon D, Escalas N, Cochard P, Glise B, Danesin C, Soula C, Sulfatase 2 promotes generation of a spinal cord astrocyte subtype that stands out through the expression of Olig2. Glia. 2019 Aug;67(8):1478-1495
1	J:242339 Ohayon D, Garces A, Joly W, Soukkarieh C, Takagi T, Sabourin JC, Agius E, Darling DS, De Santa Barbara P, Higashi Y, Stolt CC, Hugnot JP, Richardson WD, Carroll P, Pattyn A, Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone Involves the Zeb1 Transcription Factor. Cell Rep. 2016 Nov 01;17(6):1473-1481
1	J:155532 Ohno M, Hiraoka Y, Matsuoka T, Tomimoto H, Takao K, Miyakawa T, Oshima N, Kiyonari H, Kimura T, Kita T, Nishi E, Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system. Nat Neurosci. 2009 Dec;12(12):1506-13
1	J:305247 Paredes I, Vieira JR, Shah B, Ramunno CF, Dyckow J, Adler H, Richter M, Schermann G, Giannakouri E, Schirmer L, Augustin HG, Ruiz de Almodovar C, Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor-endothelial cell crosstalk. Nat Neurosci. 2021 Apr;24(4):478-488
1	J:132162 Petryniak MA, Potter GB, Rowitch DH, Rubenstein JL, Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain. Neuron. 2007 Aug 2;55(3):417-33
1	J:123645 Potzner MR, Griffel C, Lutjen-Drecoll E, Bosl MR, Wegner M, Sock E, Prolonged Sox4 expression in oligodendrocytes interferes with normal myelination in the central nervous system. Mol Cell Biol. 2007 Aug;27(15):5316-26
1	J:327338 Sartoretti MM, Campetella CA, Lanuza GM, Dbx1 controls the development of astrocytes of the intermediate spinal cord by modulating Notch signaling. Development. 2022 Aug 1;149(15):dev200750
1	J:124679 Schreiner S, Cossais F, Fischer K, Scholz S, Bosl MR, Holtmann B, Sendtner M, Wegner M, Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages. Development. 2007 Sep;134(18):3271-81
1	J:263267 Serjanov D, Bachay G, Hunter DD, Brunken WJ, Laminin beta2 Chain Regulates Retinal Progenitor Cell Mitotic Spindle Orientation via Dystroglycan. J Neurosci. 2018 Jun 27;38(26):5996-6010
1	J:168563 Shi Y, Liu JP, Gdf11 facilitates temporal progression of neurogenesis in the developing spinal cord. J Neurosci. 2011 Jan 19;31(3):883-93
1*	J:115166 Shibasaki K, Takebayashi H, Ikenaka K, Feng L, Gan L, Expression of the basic helix-loop-factor Olig2 in the developing retina: Olig2 as a new marker for retinal progenitors and late-born cells. Gene Expr Patterns. 2007 Jan;7(1-2):57-65
1	J:98431 Stolt CC, Lommes P, Friedrich RP, Wegner M, Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy. Development. 2004 May;131(10):2349-58
1	J:116148 Stolt CC, Schlierf A, Lommes P, Hillgartner S, Werner T, Kosian T, Sock E, Kessaris N, Richardson WD, Lefebvre V, Wegner M, SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. Dev Cell. 2006 Nov;11(5):697-709
1	J:340405 Talley MJ, Nardini D, Ehrman LA, Lu QR, Waclaw RR, Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon. Neural Dev. 2023 Sep 8;18(1):5
1	J:260791 Truch K, Arter J, Turnescu T, Weider M, Hartwig AC, Tamm ER, Sock E, Wegner M, Analysis of the human SOX10 mutation Q377X in mice and its implications for genotype-phenotype correlation in SOX10-related human disease. Hum Mol Genet. 2018 Mar 15;27(6):1078-1092
1	J:293532 Vaid S, Camp JG, Hersemann L, Eugster Oegema C, Heninger AK, Winkler S, Brandl H, Sarov M, Treutlein B, Huttner WB, Namba T, A novel population of Hopx-dependent basal radial glial cells in the developing mouse neocortex. Development. 2018 Oct 18;145(20):dev169276
1	J:98428 Vallstedt A, Klos JM, Ericson J, Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain. Neuron. 2005 Jan 6;45(1):55-67
1	J:311908 Vogel JK, Weider M, Engler LA, Hillgartner S, Schmitt C, Hermans-Borgmeyer I, Wegner M, Sox9 overexpression exerts multiple stage-dependent effects on mouse spinal cord development. Glia. 2020 May;68(5):932-946
1	J:196667 Vogl MR, Reiprich S, Kuspert M, Kosian T, Schrewe H, Nave KA, Wegner M, Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia. J Neurosci. 2013 Apr 10;33(15):6679-90
1	J:306250 Wang W, Cho H, Kim D, Park Y, Moon JH, Lim SJ, Yoon SM, McCane M, Aicher SA, Kim S, Emery B, Lee JW, Lee S, Park Y, Lee SK, PRC2 Acts as a Critical Timer That Drives Oligodendrocyte Fate over Astrocyte Identity by Repressing the Notch Pathway. Cell Rep. 2020 Sep 15;32(11):108147
1	J:236342 Wang W, Jossin Y, Chai G, Lien WH, Tissir F, Goffinet AM, Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling. Nat Commun. 2016 Mar 04;7:10936
1	J:297623 Wang YZ, Fan H, Ji Y, Reynolds K, Gu R, Gan Q, Yamagami T, Zhao T, Hamad S, Bizen N, Takebayashi H, Chen Y, Wu S, Pleasure D, Lam K, Zhou CJ, Olig2 regulates terminal differentiation and maturation of peripheral olfactory sensory neurons. Cell Mol Life Sci. 2020 Sep;77(18):3597-3609
1*	J:288669 Wedel M, Frob F, Elsesser O, Wittmann MT, Lie DC, Reis A, Wegner M, Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation. Nucleic Acids Res. 2020 May 21;48(9):4839-4857
1	J:260476 Weider M, Starost LJ, Groll K, Kuspert M, Sock E, Wedel M, Frob F, Schmitt C, Baroti T, Hartwig AC, Hillgartner S, Piefke S, Fadler T, Ehrlich M, Ehlert C, Stehling M, Albrecht S, Jabali A, Scholer HR, Winkler J, Kuhlmann T, Wegner M, Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning. Nat Commun. 2018 Mar 2;9(1):899
1	J:224004 Weider M, Wegener A, Schmitt C, Kuspert M, Hillgartner S, Bosl MR, Hermans-Borgmeyer I, Nait-Oumesmar B, Wegner M, Elevated in vivo levels of a single transcription factor directly convert satellite glia into oligodendrocyte-like cells. PLoS Genet. 2015 Feb;11(2):e1005008
1*	J:251778 Weng C, Ding M, Chang LS, Ren MX, Zhang HF, Lu ZN, Fu H, Ankfy1 is dispensable for neural stem/precursor cell development. Neural Regen Res. 2016 Nov;11(11):1804-1809
1	J:308527 Xing L, Kubik-Zahorodna A, Namba T, Pinson A, Florio M, Prochazka J, Sarov M, Sedlacek R, Huttner WB, Expression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility. EMBO J. 2021 Jul 1;40(13):e107093
1	J:194893 Yu K, McGlynn S, Matise MP, Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord. Development. 2013 Apr;140(7):1594-604
1	J:334091 Zhang X, Xiao G, Johnson C, Cai Y, Horowitz ZK, Mennicke C, Coffey R, Haider M, Threadgill D, Eliscu R, Oldham MC, Greenbaum A, Ghashghaei HT, Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain. iScience. 2023 Mar 17;26(3):106242
1	J:223471 Zhao X, Chen Y, Zhu Q, Huang H, Teng P, Zheng K, Hu X, Xie B, Zhang Z, Sander M, Qiu M, Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor. PLoS One. 2014;9(10):e109171
1	J:185534 Zhu X, Zuo H, Maher BJ, Serwanski DR, Loturco JJ, Lu QR, Nishiyama A, Olig2-dependent developmental fate switch of NG2 cells. Development. 2012 Jul;139(13):2299-307